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61.
Edwin C. Constable Catherine E. Housecroft Elaine A. Medlycott Markus Neuburger Federica Reinders Sbastien Reymann Silvia Schaffner 《Inorganic chemistry communications》2008,11(7):805-808
The solid state structure of [Ru(Phtpy)2][PF6]2 · 4MeCN has been determined (Phtpy = 4′-phenyl-2,2′:6′,2″-terpyridine); [Ru(Phtpy)2]2+ cations pack into sheets by virtue of {M(tpy)2}2 embraces, and the MeCN solvent molecules are involved in NH–C interactions which prevent the efficient packing of adjacent sheets. Comparisons with related structures lead to some generalizations about packing motifs in salts containing [M(Phtpy)2]2+ or [M(pytpy)2]2+ cations (pytpy = 4′-pyridyl-2,2′:6′,2″-terpyridine). 相似文献
62.
Viviane Ponath Nathalie Hoffmann Leonie Bergmann Christina Mder Bilal Alashkar Alhamwe Christian Preußer Elke Pogge von Strandmann 《International journal of molecular sciences》2021,22(4)
NKp30 (Natural Cytotoxicity Receptor 1, NCR1) is a powerful cytotoxicity receptor expressed on natural killer (NK) cells which is involved in tumor cell killing and the regulation of antitumor immune responses. Ligands for NKp30, including BAG6 and B7-H6, are upregulated in virus-infected and tumor cells but rarely detectable on healthy cells. These ligands are released by tumor cells as part of the cellular secretome and interfere with NK cell activity. BAG6 is secreted via the exosomal pathway, and BAG6-positive extracellular vesicles (EV-BAG6) trigger NK cell cytotoxicity and cytokine release, whereas the soluble protein diminishes NK cell activity. However, the extracellular format and activity of B7-H6 remain elusive. Here, we used HEK293 as a model cell line to produce recombinant ligands and to study their impact on NK cell activity. Using this system, we demonstrate that soluble B7-H6 (sB7-H6), like soluble BAG6 (sBAG6), inhibits NK cell-mediated target cell killing. This was associated with a diminished cell surface expression of NKG2D and NCRs (NKp30, NKp40, and NKp46). Strikingly, a reduced NKp30 mRNA expression was observed exclusively in response to sBAG6. Of note, B7-H6 was marginally released in association with EVs, and EVs collected from B7-H6 expressing cells did not stimulate NK cell-mediated killing. The molecular analysis of EVs on a single EV level using nano flow cytometry (NanoFCM) revealed a similar distribution of vesicle-associated tetraspanins within EVs purified from wildtype, BAG6, or B7-H6 overexpressing cells. NKp30 is a promising therapeutic target to overcome NK cell immune evasion in cancer patients, and it is important to unravel how extracellular NKp30 ligands inhibit NK cell functions. 相似文献
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This paper presents an innovative method to analyze and visualize time-dependent evolution of features. The analysis and visualization
of time-dependent data are complicated because of the immense number of data involved. However, if the scientist's main interest
is the evolution of certain features, it suffices to show the evolution of these features.
The task of the visualization method is to extract the features from all frames, to determine the correspondences between
features in successive frames, to detect significant events or stages in the evolution of the features, and, finally, to visualize
the results. The method described here performs all these steps, and it is applied to a number of applications. 相似文献
66.
R D Reinders M F Weber L J Lipman J Verhoeff P G Bijker 《International journal of food microbiology》2001,66(1-2):79-83
The Dutch government and the meat industry, recognising VTEC as having important public health, meat quality and economic implications, have taken a number of initiatives within the last 5 years to control VTEC in livestock and meat. These initiatives, brought together last year in a 'Masterplan VTEC', include short-, middle- and long-term priorities. Short-term priorities include advice on interventions in the cases of an outbreak of VTEC associated with a cattle herd, the implementation of handbooks for Good Manufacturing Practice (GMP) in slaughterhouses and deboning plants, and the execution of an action programme on zero-tolerance to faecal contamination of carcasses. Mid-term activities include surveillance of the occurrence of VTEC and other enteropathogens in livestock and meat, and the investigations of VTEC population dynamics in dairy farms, transportation and farm hygiene. In the longer term, this programme aims to produce a system of Integrated Quality Assurance, consolidating effective measures to control VTEC in Dutch livestock and meat, and integrating emerging means for control and prevention. 相似文献
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E. Dinslage Bames v. Schroeder Lars Erlandsen Schwaibold Kluge Erich Opitz A. Schmitz W. Ludorff Schloemer Leonie Haack F. Weygand Hans Freytag W. Schreiber Reichard Griebel J. Großjeld R. Grau Johannes Wolf K. Felix Bartschat W. von Pantschenko-Jurewicz Rodewald Carls Beckel H. Mohler Zacher W. Hämmerle M. Steinei Ed. Rentz Brüning O. Windhausen Wilhelm Neumann W. Wodsak Pawletta Karl Sauer Kanitz Bäurle Felicitas Rolleri Haevecker Jesser L. Norpoth W. Sutthoff Rob Jungkunz G. Stamm Hans Hawelka Hahn H. Leopold Ad. Hanak Diemair K. Höll 《European Food Research and Technology》1941,82(4):356-399
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